sipV [2019-06-06 12:30:58]

signal peptidase I

Locus: BSU10490

Isoelectric point: 10.12

Molecular weight: 18.81 kDa

Protein length: 168 aa

Gene length: 507 bp

Function: protein secretion

Product: signal peptidase I

Essential: no

Synonyms: yhjF

Genomic Context

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Categories containing this gene/protein

• Information processing → Protein synthesis, modification and degradation → Protein secretion
• Groups of genes → Membrane proteins

Gene

Coordinates: 1,122,175 1,122,681

The protein

Catalyzed reaction/ biological activity

• Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins (according to Swiss-Prot)

Protein family

• peptidase S26 family (according to Swiss-Prot)

Paralogous protein(s)

• SipT, SipS, SipU

Structure

• 4NV4 (from B. anthracis, 47% identity)

Localization

• cell membrane (according to Swiss-Prot)

Expression and Regulation

Operons

• Genes: yhjE-sipV
  Description: PubMed

  Regulatory mechanism

  • LexA: repression, PubMed, in LexA regulon

  Regulation

  • induced upon DNA damage (LexA) PubMed

Biological materials

Mutant

• BKE10490 (sipV::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGTTACTGTCTCCCTCCA, downstream forward: _UP4_TAAAAAGACGCTAATTGAAG
• BKK10490 (sipV::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGTTACTGTCTCCCTCCA, downstream forward: _UP4_TAAAAAGACGCTAATTGAAG

Labs working on this gene/protein

• Jan Maarten van Dijl, Groningen, Netherlands

References

Reviews

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Original publications

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